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Paradi Mirmirani, a volunteer associate professor at UCSF, told SFGATE in an email that the study found hair loss was "strongest" in patients using higher doses of GLP-1s to treat obesity or for rapid weight loss but less common in patients taking lower doses of GLP-1s to treat Type 2 diabetes

Bacterial contamination accelerates peptide degradation and could theoretically cause infection, though the sublingual vehicle itself often contains antimicrobial properties

The primary reason doses increase is to move from a tolerability phase into a therapeutically active range, not simply to intensify the effect